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Lingling Kong, PhD

Research Associate

Lingling.JPG

Education and Training:

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  • Doctoral/Graduate​

    • PhD, Peking University, Beijing, China

      • Neurobiology​

    • MD, Zhengshou University, Zhengzhou, China​​​

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Previous Positions:

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  • Assistant lecturer in Human Histology and Embryology

    • Xinxiang Medical College, Xinxiang, China

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Research Interests:

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Genetics and pathogenesis and therapeutic development for inherited motor neuron disease and other related neurological diseases

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Current Projects:

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Developmental and degenerative abnormalities in spinal muscular atrophy (SMA) and therapeutic implications. 

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Selected Publications:

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  1. Impaired prenatal motor axon development necessitates early therapeutic intervention in severe SMA. Kong LL, Valdivia DO, Simon CM, Hassinan CW, Delestrée N, Ramos DM, Park JH, Pilato CM, Xu X, Crowder M, Grzyb CC, King ZA, Petrillo M, Swoboda KJ, Davis C, Lutz CM, Stephan AH, Zhao X, Weetall M, Naryshkin NA, Crawford TO, Mentis GZ, Sumner CJ. Science Translational Medicine 2021; 13(578).

  2. Survival motor neuron protein in motor neurons determines synaptic integrity in spinal muscular atrophy. Martinez TL1, Kong L, Wang X, Osborne MA, Crowder ME, Van Meerbeke JP, Xu X, Davis C, Wooley J, Goldhamer DJ, Lutz CM, Rich MM, Sumner CJ. J Neurosci. 2012;32(25):8703- 15. 

  3. Overexpression of IGF-1 in muscle attenuates disease in a mouse model of spinal and bulbar muscular atrophy. Palazzolo I, Stack C, Kong L, Musaro A, Adachi H, Katsuno M, Sobue G, Taylor JP, Sumner CJ, Fischbeck KH, Pennuto M. Neuron. 2009;63(3):316-28.

  4. Impaired synaptic vesicle release and immaturity of neuromuscular junctions in spinal muscular atrophy mice. Kong L, Wang X, Choe DW, Polley M, Burnett BG, Bosch-Marcé M, Griffin JW, Rich MM, Sumner CJ. J Neurosci. 2009;29(3):842-51.

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Contact:

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lkong8@jhmi.edu

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