Previous Positions:
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Information Technology Manager: Neurology Intraoperative Monitoring (IOM) department, Johns Hopkins Hospital
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Undergraduate Research Assistant: Brain Tumor Stem Cell Laboratory, Johns Hopkins School of Medicine
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Dr. Alfredo Quiñones
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Research Interests:
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Gain-of-function mutations of the calcium-permeable, cell surface-expressed cation channel transient receptor potential vanilloid 4 (TRPV4) and the forms of spinal muscular atrophy and Charcot-Marie-Tooth disease associated with such mutations.
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Disruptions of blood-neural barriers (BNBs) and the role they play in the pathogenesis of many chronic and acute neurodegenerative disorders.
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Reversibility of neurological and BNB phenotypes with small molecule treatments in vivo and implications for future targeted opening and closing of the BNB for non-neurovascular permeable drug administration
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Current Projects:
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A novel knock-in mouse model of trpv4 channelopathy: elucidating in vivo effects of neuropathy-causing trpv4 mutations
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Characterization of Blood Nerve Barrier integrity in a knock-in mouse model of a trpv4 channelopathy
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To investigate whether TRPV4-mediated BNB deficits cause neuronal dysfunction and/or degeneration in vivo and determine reversibility with TRPV4 small molecule antagonism
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Characterization of a humanized knock-in mouse model of a trpv4 channelopathy
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Selected Publications:
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"TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca2+" (reference number: NCOMMS-19-35488-T), submitted.
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Contact:
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